Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry has been used to examine ion-molecule reactions in xenon/ozone and xenon/methane/ozone mixtures. The cationic ozone derivatives, formed in these mixtures, are found to react with xenon, yielding a variety of stable products containing the Xe-O bond, i.e., XeO+, XeO2+, XeO3+, XeOH+, and XeOH2+. Estimated values for the Xe-O bond strength in the XeO+ and XeOH+ ions range around 51 and 52 kcal mol(-1), respectively. Both these ions exhibit distinct oxidative oxygenating properties toward some simple inorganic and organic substrates. In some representative cases, a stepwise oxidation mechanism is observed, involving the homolytic scission of a bond of the substrate by XeO+, followed by intracomplex ion-radical recombination with elimination of the Xe fragment.