A specially designed tubular microreactor with independent control of feed preheat as well as catalyst temperature and allowing to rapidly quench reaction products was used to test performance of supported Pt-based monolithic catalysts in the reaction of propane oxidative dehydrogenation at short contact times. To minimize the impact of undesired homogeneous reactions capable of decreasing propylene selectivity, proprietary straight-channel thin-wall high cell density corundum micromonoliths were chosen as supports. Catalytic properties of supported platinum were modified by using promoters known as dehydrogenation catalysts (tin, zinc aluminate spinel, transition metal pyrophosphates) as well as by tuning reaction mixture composition (propane/oxygen ratio, water and hydrogen content). In the operation temperature range up to 900 degrees C with contact times similar to 0.03-0.1 s, ethylene/propylene selectivities were found to strongly depend upon the chemical composition of the active component and type of feed. The results thus obtained demonstrate that for Pt-based catalysts, propylene yield can be substantially improved by suppressing secondary reactions of deep oxidation and cracking.