초임계 이산화탄소를 이용한 일일초로부터 vindoline과 catharanthine의 추출속도

송규민; 홍원희; 이흔; 곽상수; 유장열

HWAHAK KONGHAK, Vol.31, No.3, 318-324, June, 1993

Export Citation

초임계 이산화탄소를 이용한 일일초로부터 vindoline과 catharanthine의 추출속도

Extraction Rates of Vindoline and Catharanthine from Catharanthus roseus with Supercritical Carbondioxide

송규민, 홍원희, 이흔, 곽상수, 유장열

초록

초임계 이산화탄소를 이용하여 전처리된 일일초 잎으로부터 vindoline과 catharanthine을 추출하였으며 여러 온도 및 압력 조건에 따른 이들의 물질전달계수를 구하였다. 추출된 vindoline과 catharanthine의 수율을 초임계 이산화탄소의 환산 밀도와 비교하였으며 온도에 따른 관계 상수값을 구하였다. 물질전달의 해석은 vindoline과 catharanthine의 고체상과 유체상간의 물질전달계수를 정의하여 구한 정상상태를 이용하였다. 정상상태해를 통해 구한 Sherwood 수는 Reynolds 수와 Schmidt 수의 함수로 표현하였다.

Vindoline and catharanthine were extracted from the pretreated leaves of Catharanthus roseus using supercritical carbon dioxide and their mass transfer coefficients were determined in various conditions of temperature and pressure. Extraction yields of vindoline and catharanthine were compared with the reduced density of supercritical carbon dioxide and the relational parameters were calculated in each given temperature. Defining the mass transfer coefficient of vindoline and catharanthine between solid phase and fluid phase, the mass transfer was studied by steady state analysis. Sherwood number obtained by this method was expressed as a function of Reynolds and Schmidt number.

[References]

Jones WE, U.S. Patent, 3,932,417 (1976)
Miura Y, Hirata K, Kurando N, Miyamoto K, UchidaK, Planta Med., 54, 18 (1988)
Hirata K, Yamanaka A, Kurano N, Miyamoto K, Miura Y, Agric. Biol. Chem., 51(5), 1311 (1987)
Renaudin JP, J. Chromatogr., 291, 165 (1984)
Song KM, M.S. Thesis, KAIST, Taejon (1992)
Rowlinson TS, Richardson MJ, Adv. Chem. Phys., 2, 85 (1959)
Ruthven DM, "Principles of Adsorption and Adsorption Process," Wiley-Interscience (1984)
Brunner G, Ber. Bunsenges. Phys. Chem., 88, 887 (1984)
Angus S, Armstrong B, deReuck KM, "International Thermodynamic Tables of the Fluid State Carbon Dioxide," First Edition, Pergamon Press (1976)
Reid RC, Prausnitz JM, Poling BE, "The Properties of Gases & Liquids," Fourth Edition, McGraw-Hill (1989)
Debenedetti PG, Reid RC, AIChE J., 32(12), 2034 (1986)
Tan CS, Liang SK, Liou DC, Chem. Eng. J., 38, 17 (1988)
Song KM, Park SW, Lee H, Hong WH, Kwak SS, Liu JR, Korean J. Biotechnol. Bioeng., 6(4), 407 (1991)
Lee H, Hong WH, Yoon JH, Song KM, Yang SM, Biotechnol. Tech., 6(2), 127 (1992)
Song KM, Yoon JH, Lee H, Hong WH, Yang SM, "Biochemical Engineering for 2001," APBioChEC'92, 566-568 (1992)

[Referenced By]

[1] Jones WE, U.S. Patent, 3,932,417 (1976)

[2] Miura Y, Hirata K, Kurando N, Miyamoto K, UchidaK, Planta Med., 54, 18 (1988)

[3] Hirata K, Yamanaka A, Kurano N, Miyamoto K, Miura Y, Agric. Biol. Chem., 51(5), 1311 (1987)

[4] Renaudin JP, J. Chromatogr., 291, 165 (1984)

[5] Song KM, M.S. Thesis, KAIST, Taejon (1992)

[6] Rowlinson TS, Richardson MJ, Adv. Chem. Phys., 2, 85 (1959)

[7] Ruthven DM, "Principles of Adsorption and Adsorption Process," Wiley-Interscience (1984)

[8] Brunner G, Ber. Bunsenges. Phys. Chem., 88, 887 (1984)

[9] Angus S, Armstrong B, deReuck KM, "International Thermodynamic Tables of the Fluid State Carbon Dioxide," First Edition, Pergamon Press (1976)

[10] Reid RC, Prausnitz JM, Poling BE, "The Properties of Gases & Liquids," Fourth Edition, McGraw-Hill (1989)

[11] Debenedetti PG, Reid RC, AIChE J., 32(12), 2034 (1986)

[12] Tan CS, Liang SK, Liou DC, Chem. Eng. J., 38, 17 (1988)

[13] Song KM, Park SW, Lee H, Hong WH, Kwak SS, Liu JR, Korean J. Biotechnol. Bioeng., 6(4), 407 (1991)

[14] Lee H, Hong WH, Yoon JH, Song KM, Yang SM, Biotechnol. Tech., 6(2), 127 (1992)

[15] Song KM, Yoon JH, Lee H, Hong WH, Yang SM, "Biochemical Engineering for 2001," APBioChEC'92, 566-568 (1992)