Speeds of sound of (methyl ethanoate + methanol + 1-propanol), (methyl ethanoate + methanol + 2-propanol), (methyl ethanoate + methanol + 2-butanol) and (methyl ethanoate + methanol + 2-methyl-2-butanol) at T = 298.15 K and atmospheric pressure, have been measured over the whole range of mixture compositions. In addition, the speed of sound of (methyl ethanoate + 1-propanol), (methanol + 1-propanol), (methyl ethanoate + 2-propanol), (methanol + 2-propanol), (methyl ethanoate + 2-butanol), (methanol + 2-butanol), (methyl ethanoate + 2-methyl-2-butanol), (methanol + 2-methyl-2-butanol) have been measured. Deviations in isentropic compressibilities for the binary and ternary systems were calculated and fitted to the Redlich-Kister and Cibulka equations, respectively, in order to estimate the fitting parameters and the standard deviations between calculated and experimental data. A comparison in terms of deviation in isentropic compressibilities is made by variation of the type of groups in the carbon that has the hydroxyl group. A method has been used to predict the speed of sound of binary and ternary mixtures and the results were compared with the experimental data.