Different mono (Pt), bi (Pt-Sn, Pt-Pb, Pt-Ga) and trimetallic (Pt-Sn-Ga) catalysts based on Pt and supported on different materials (Al2O3, Al2O3-K and ZnAl2O4) were tested under severe process conditions in the propane dehydrogenation reaction (both in continuous and in pulse reactors). Results show that the Pt-Sn-Ga/ZnAl2O4 catalyst has a better and more stable performance in propane dehydrogenation (high yield to propene and low coke deposition), than the other bi- and trimetallic systems and a commercial catalyst. Thus, the use of an adequate support (ZnAl2O4) in combination with the addition of Ga to the Pt-Sn bimetallic system enhances the catalytic performance.