This work reports the modelling and simulation of a hybrid process, based on the combination of distillation and pervaporation, for the separation of azeotropic mixtures of alcohol-ether. After having selected the separation of methanol-2-metoxi-2,2-dimethyl ethane (ETHER) as a motivating example the mathematical modelling of the distillation column was achieved and used together with a mass transfer model previously reported for the pervaporation operation in order to simulate the behaviour of the hybrid process for different compositions of the feed stream (case 1: 3.2 wt% methanol, 55.4 wt% C-4, 41.4 wt% ETHER, and case 2: 5.2 wt% methanol, 42 wt% C-4, 52.8 wt% ETHER). Simulation tasks were carried out with the process modelling system gPROMS and the results of alternative process configurations that result from the relative location of the separation technologies have been compared on the basis of the required membrane area. Finally, the design of the pervaporation unit including the overall processing costs is reported. Copyright