In this article, a strategy for automatic hazard analysis of batch process and the integrated automatic hazard analysis systems are proposed. The suggested process models for hazard analysis are based on multimodeling approach, which aims the improvement of the effectiveness and efficiency of reasoning process by cooperation of multiple models, According to the multimodeling concept, four process representation models, including operational, material, behavioral and functional knowledge bases, and four hazard inference algorithms are established. For a case study, a batch pharmaceutical process is tested and a maloperation analysis is performed,, and the case study showed more successful capture of hazard information using the devised analysis system than the traditional systems.