PLA-POE-PLA 블록공중합체 분산액에 의한 생체적합성의 평가 및 특성

이찬우; 김홍; 송경헌; 문성일; Chan Woo Lee; Hong Kim; Kyung Hun Song; Sung Il Moon

Polymer(Korea), Vol.26, No.2, 174-178, March, 2002

Export Citation

PLA-POE-PLA 블록공중합체 분산액에 의한 생체적합성의 평가 및 특성

Characterization and Biocompatibility with Dispersed Solution of PLA-POE-PLA Block Copolymer

이찬우^†, 김홍, 송경헌¹, 문성일²

호서대학교 공과대학 첨단산업기술전공
¹배재대학교 의류학부
²일본교토공과대학 기능성고분자학과

Chan Woo Lee^†, Hong Kim, Kyung Hun Song¹, and Sung Il Moon²

Department of Innovative Industrial & Technology, Hoseo University, Asan-City 336-795, Korea
¹Department of Clothing & Textiles, Paichai University, 439-6, Doma 2-dong, Seo-gu, Daejeon, Korea
²Department of Polymer Science and Engineering, Kyoto Institute of Technology, Kyoto 606-8585, Japan

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초록

조성비가 서로 다른 각종의 PLLA-POE-PLLA와 PDLA-POE-PDLA블록공중합체의 합성을 실시하여 모든 공중합체를 고수율이며 다분산도가 현저하게 작은 생성물을 얻었으며, 그 결과 체온 부근인 37 ℃에서는 0.1 g/mL PLLA-POE-PLLA 분산액과 0.1 g/mL PDLA-POE-PDLA의 혼합분산액에서 겔의 형성이 관찰되었다. 또한 PLLA-POE-PLLA분산액과 비교하여 PLLA-POE-PLLA분산액과 PDLA-POE-PDLA분산액을 혼합한 분산액의 흐림점이 높아지는 것을 확인하였으며 고농도일수록 흐림점이 낮아지는 현상도 확인되었다.

PLLA-POE-PLLA block copolymers were prepared using PLLA and POE with different compositions. Copolymers were obtained in high yield and the polydispersity of the copolymers was very narrow. A dispersed solution of 0.1 g/mL of PLLA-POE-PLLA copolymer was mixed with a dispersed solution of 0.1 g/mL of PDLA-POE-PDLA copolymer. Gel formation was observed from the mixed product obtained at the human body temperature of 37 ℃. The mixed product comprising PDLA-POE-PDLA and PLLA-POE-PLLA was found to have higher cloud points than that of PLLA-POE-PLLA copolymer. The cloud points decreased with increasing the concentration of the mixed copolymer dispersed solution.

Keywords:block copolymer;polydispersity;dispersed solution;cloud point

[References]

Lee CW, Kimura Y, Bull. Chem. Soc. Jpn., 69, 1787 (1996)
Casey DJ, Huffman KR, (Am. Cyanamid Co.) US Patent 4438253 (1948)
Vitalis EA, Chem. Abstr., (Am. cyanamid Co.), US Patent 2917410, 54, 7173d (1960)
Tsuji H, Ikada Y, Macromolecules, 25, 5719 (1992)
Tsuji H, Ikada Y, Macromol. Phys., 197, 3483 (1996)
Ikada Y, Jamshidi K, Tsuji H, Hyon SH, Macromolecules, 20, 904 (1987)
Tsuji H, Ikada Y, Macromolecules, 26, 6918 (1993)
Tsuji H, Horii F, Hyon SH, Ikada Y, Macromolecules, 24, 2719 (1991)
Tsuji H, Hyon SH, Ikada Y, Macromolecules, 24, 5651 (1991)
Tsuji H, Hyon SH, Ikada Y, Macromolecules, 24, 5657 (1991)
Tsuji H, Hyon SH, Ikada Y, Macromolencules, 25, 2940 (1992)
Tsuji H, Horii F, Nakagawa M, Ikada Y, Odani H, Kitamura R, Macromolecules, 25, 2940 (1992)
Tsuji H, Ikada Y, Hyon SH, Kimura Y, Kitao T, J. Appl. Polym. Sci., 51(2), 337 (1994)
Shiraki K, Tsuji H, Hyon SH, Ikada Y, Nakamura T, Shimiizu Y, Polym. Prepr, Jpn., 39, 584 (1990)
Kim BS, Hrkach JS, Langer R, Biomaterials, 21, 259 (2000)

[Referenced By]

[1] Lee CW, Kimura Y, Bull. Chem. Soc. Jpn., 69, 1787 (1996)

[2] Casey DJ, Huffman KR, (Am. Cyanamid Co.) US Patent 4438253 (1948)

[3] Vitalis EA, Chem. Abstr., (Am. cyanamid Co.), US Patent 2917410, 54, 7173d (1960)

[4] Tsuji H, Ikada Y, Macromolecules, 25, 5719 (1992)

[5] Tsuji H, Ikada Y, Macromol. Phys., 197, 3483 (1996)

[6] Ikada Y, Jamshidi K, Tsuji H, Hyon SH, Macromolecules, 20, 904 (1987)

[7] Tsuji H, Ikada Y, Macromolecules, 26, 6918 (1993)

[8] Tsuji H, Horii F, Hyon SH, Ikada Y, Macromolecules, 24, 2719 (1991)

[9] Tsuji H, Hyon SH, Ikada Y, Macromolecules, 24, 5651 (1991)

[10] Tsuji H, Hyon SH, Ikada Y, Macromolecules, 24, 5657 (1991)

[11] Tsuji H, Hyon SH, Ikada Y, Macromolencules, 25, 2940 (1992)

[12] Tsuji H, Horii F, Nakagawa M, Ikada Y, Odani H, Kitamura R, Macromolecules, 25, 2940 (1992)

[13] Tsuji H, Ikada Y, Hyon SH, Kimura Y, Kitao T, J. Appl. Polym. Sci., 51(2), 337 (1994)

[14] Shiraki K, Tsuji H, Hyon SH, Ikada Y, Nakamura T, Shimiizu Y, Polym. Prepr, Jpn., 39, 584 (1990)

[15] Kim BS, Hrkach JS, Langer R, Biomaterials, 21, 259 (2000)