Optimal operations of extractive distillation for regular and middle-vessel batch columns are presented based oil a profit function. Detailed models are used for the rigorous dynamic optimization considering all operational decision variables, including reflux ratio, solvent feed rate, heat duties, and possible product withdrawals during the process. Optimal feed distribution and stream configuration at the middle section of the middle-vessel column are investigated. Separation of a minimum boiling azeotropic binaty mixture (acetone and methanol using water as solvent) involving different separation duties and feed compositions is presented as a case study. The performance of the middle-vessel column is significantly influenced by the middle-section stream configuration, with the best profit when the stream configuration is allowed to vary during the operation. The optimal operating policy for the middle-vessel column involved the feed being charged mainly to the reboiler still with low holdup in the middle vessel during the operation.