분산중합에 의한 가교 고분자 마이크로스피어의 제조 및 흡유특성

김공수; 이영근; 임장규; 김태경; Kong Soo Kim; Young Gyun Lee; Jang Gyu Lim; Tae Kyung Kim

Journal of the Korean Industrial and Engineering Chemistry, Vol.13, No.5, 462-467, August, 2002

Export Citation

분산중합에 의한 가교 고분자 마이크로스피어의 제조 및 흡유특성

Preparation and Oil Absorption Properties of Crosslinked Polymer Microspheres by Dispersion Polymerization

김공수, 이영근, 임장규, 김태경^†

충북대학교 화학공학과, 충북 361-763

Kong Soo Kim, Young Gyun Lee, Jang Gyu Lim, and Tae Kyung Kim^†

Department of Industrial & Chemical Engineering Graduate School, Chungbuk National University, Chungbuk 361-763, Korea

E-mail:

초록

본 연구에서는 Poly(butyl methacrylate) (PBMA), polystyrene (PS), poly(methyl methacrylate) (PMMA) 마이크로스피어를 제조하여 가교도에 따른 흡유특성과 방출특성을 시험하였다. 이들의 마이크로스피어는 이소프로필 알코올 중에서 hydroxy propyl methyl cellulose (HPMC)와 acacia의 분산안정제 존재하에 butyl methacrylate (BMA), styrene (St), methyl metacrylate (MMA) 그리고 ethylene glycol dimethacrylate (EGDMA)로부터 분산중합 방법으로 제조하였으며, 마이크로스피어의 입자크기와 분포에 대한 분산안정제, 모노머, 가교제의 농도와 교반속도의 영향을 조사하였다. 또한 PBMA, PS 그리고 PMMA 마이크로스피어에 대한 tea tree oil과 vitamin E에 대한 흡유도와 방출거동을 시험하였다. 마이크로스피어의 흡유도는 가교도가 증가할 수록 감소하였고, vitamin E의 방출속도는PBMA < PS < PMMA 순으로 증가하였다.

Poly(butyl methacrylate) (PBMA), polystyrene (PS) and poly(methly methacrylate) (PMMA) microspheres with different crosslinking densities were prepared in aqueous media. The release behavior of these microspheres for vitamin E in ethanol was observed. Crosslinked microspheres were prepared from butyl methacrylate (BMA), styrene (St), methyl metacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of hydroxy propyl methyl cellulose (HPMC) and acacia in iso-propryl alcohol medium by dispersion polymerization. The effects of concentration of dispersion stabilizer, monomer, crosslinking agent and stirring speed on particle size and size distribution of microspheres were investigated. The oil absorption degree of PBMA, PS and PMMA microspheres for tea tree oil and vitamin E and drug release properties were determined. Their oil absorption degree was decreased with the crosslinking degree and release rate of vitamin E from the microspheres was increased in the order of PBMA < PS < PMMA.

Keywords:butyl methacrylate;styrene;methyl metacrylate;microspheres;dispersion polymerization

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[2] Arshady R, Colloid Polym. Sci., 270, 717 (1992)

[3] Thomson B, Rudin A, Lajoie G, J. Polym. Sci. A: Polym. Chem., 33(3), 345 (1995)

[4] Tseng CM, Lu YY, El-aasser MS, Vanderhoff JW, J. Polym. Sci. A: Polym. Chem., 24, 2995 (1986)

[5] Peula JM, Hidalgo-Alvarez R, Santos R, Forcada J, DeLasNieves FJ, J. Mater. Sci., 6, 779 (1995)

[6] Sakuma S, Sudo R, Suzuki N, Kikuchi H, Akashi M, Hayashi M, Int. J. Pharm., 177, 161 (1999)

[7] Mayville FC, Partch RE, Matuevic E, J. Colloid Interface Sci., 120, 135 (1987)

[8] Muller RH, Dingler A, Eur. Cosmet., 7, 19 (1998)

[9] Muller RH, Mehnert W, Lucks TS, zurMuhlen A, Weyhers H, Freitas C, Ruhl D, Eur. J. Pharm. Biopharm., 41, 62 (1995)

[10] Heiati H, Tawashi R, Phillips NC, J. Microencapsul., 15(2), 173 (1998)

[11] Eury R, Patel R, Longe K, Cheng T, Nacht S, Chemtech., 22, 42 (1992)

[12] Masini V, Bonte F, Meybeck A, Wepierre J, J. Pharm. Sci., 82, 17 (1993)

[13] Perugini P, Genta I, Pavanetto F, Conti B, Scalia S, Int. J. Pharm., 196, 51 (2000)

[14] Embil K, Nacht S, J. Microencapsul., 13(5), 575 (1996)

[15] Jenning V, Gysler N, Korting MS, Gohla SH, Eur. J. Pharm. Biopharm., 49, 211 (2000)