n-Decane hydroconversion has been investigated on bifunctional catalysts comprising bimetallic Pt-Pd clusters supported on an AlMCM-41 (n(Si)/n(Al) = 23) mesoporous molecular sieve. The catalytic activity of the bimetallic Pt-Pd catalysts is higher than that of the monometallic Pt and Pd catalysts. The good balance between the two catalytic functions, namely acid sites and metal sites, also results in a higher isomer yield at a substantially lower reaction temperature. Moreover, cracking on the metal sites (hydrogenolysis) is largely suppressed over certain bimetallic catalysts.