상 분리법을 이용한 Poly(L-lactic acid) Scaffold 제조에 미치는 Pluronics의 영향

김고은; 김현도; 이두성; Go Eun Kim; Hyun Do Kim; Doo Sung Lee

Polymer(Korea), Vol.26, No.6, 821-828, November, 2002

Export Citation

상 분리법을 이용한 Poly(L-lactic acid) Scaffold 제조에 미치는 Pluronics의 영향

Effect of Added Pluronics on Fabrication of Poly(L-lactic acid) Scaffold via Thermally-Induced Phase Separation

김고은, 김현도, 이두성^†

기능성 고분자 신소재 연구센터

Go Eun Kim, Hyun Do Kim, and Doo Sung Lee^†

Center for Advanced Functional Polymers, Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Kyungki 440-746, Korea

E-mail:

초록

미량의 Pluronics가 첨가된 PLLA/1,4-dioxane/water의 삼성분계상을 온도 변화로 유도된 상 분리법을 이용하여 10~300 μm의 공극 크기를 가지며 공극 간의 연결성이 우수한 PLLA 다공성 지지체를 제조하였다. 순수한 PLLA 용액에 Pluronics를 첨가하면 상 분리 온도가 P-123

Regular and highly interconnected macroporous poly(L-lactic acid)(PLLA) scaffolds with pore size of 10~300 μm were fabricated through thermally induced phase separation of PLLA-dioxane-water ternary system in the presence of a small amount of Pluronics. Addition of Pluronics to the ternary system raised the cloud-point temperature curve in the order of P-123

Keywords:highly interconnection;Pluronics;PLLA-dioxane-water;PEO block;spinodal region

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[2] Vacanti CA, Vacanti JP, "Function Organ Replacement: The New Technology of Tissue Engineering," ed. by R.L. Tawes, Surgical Technology, London (1991)

[3] Suh H, Polym. Sci. Technol., 10(6), 710 (1999)

[4] Anthony A, Mooney DJ, Vacanti JP, Langer R, "Synthetic Biodegradable Polymer Scaf-fold," p. 51, Birkauser Press, Boston (1997)

[5] Mikos AG, Sarakinos G, Leite SM, Vacanti JP, Langer R, Biomaterials, 14(5), 323 (1993)

[6] Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP, Polymer, 35(5), 1068 (1994)

[7] Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R, Biomaterials, 17, 1417 (1996)

[8] Whang K, Thomas CH, Healy KE, Nuber G, Polymer, 36(4), 837 (1995)

[9] Khang G, Jeon JH, Cho JC, Lee HB, Polym.(Korea), 23(3), 471 (1999)

[10] Nam YS, Park TG, J. Biomed. Mater. Res., 47, 8 (1999)

[11] Nam YS, Park TG, Biomaterials, 20, 1783 (1999)

[12] Vandewitte P, Dijkstra PJ, Vandenberg JW, Feijen J, J. Membr. Sci., 117(1-2), 1 (1996)

[13] Olabisi O, Robeson LM, Shaw MT, "Polymer-Polymer Misibility," Academic Press, Inc., New York (1979)

[14] Schugens C, Maquet V, Grandfils C, Jerome R, Teyssie P, Polymer, 37(6), 1027 (1996)

[15] Vandewitte P, Dijkstra PJ, Vandenberg JW, Feijen J, J. Polym. Sci. B: Polym. Phys., 34(15), 2553 (1996)

[16] Hua FJ, Kim GE, Lee DS, J. Biomed. Mater. Res., 63(2), 161 (2002)

[17] Hua FJ, Nam JD, Lee DS, Macromol. Rapid Commun., 22, 1053 (2001)

[18] Schugens C, Maquet V, Grandfils C, Jerome R, Teyssie P, J. Biomed. Mater. Res., 30, 449 (1996)

[19] Nace VM, "Nonionic Surfactants," Marcel Dekker, Inc., New York (1996)

[20] Kawakatsu T, Kawasaki K, Furusaka M, Okabayashi H, Kanaya T, J. Chem. Phys., 99(10), 8200 (1993)

[21] Kawakatsu T, Kawasaki K, Furusaka M, Okabayashi H, Kanaya T, J. Chem. Phys., 102(5), 2247 (1995)