A kinetic model has been developed for the degradation of organic pollutants, by considering both the decomposition of ozone molecules and the interaction between ozone and hydrogen peroxide in the formation of a hydroxyl radical, and the subsequent reactions. Rate equations were derived for the depletion of ozone and pollutants in the advanced oxidation processes (known as the peroxone oxidation). Experiments were carried out at 298 K in the pH range 3 to 11. Kinetic data obtained experimentally from the hydrogen peroxide-ozone reaction and advanced oxidation of vinyl chloride were analyzed by using the proposed rate equations, indicating that the depletion rate of ozone increases with the concentrations of ozone, hydrogen peroxide, and hydroxyl ion, as predicted by the kinetic model.