The growth of Ag clusters on preadsorbed oxygen and oxide-covered Mo(112) has been investigated using scanning tunneling microscopy (STM). The objective of these experiments is the synthesis of adjacent areas on a surface with distinctly different metal-support, interactions in order to investigate the relationship between the morphology of a supported metal cluster and the strength of the cluster-support interaction. The STM results show that more. highly dispersed Ag clusters with a greater number density are obtained on that surface that interacts to a greater extent with the metal. Heating leads to the formation of two-dimensional-Ag nanostructures on oxygen-free Mo(112) (strong metal-support interaction) and three-dimensional cluster growth on oxide-covered Mo(112) (relatively weak metal-support interaction).