화학공학소재연구정보센터
Polymer Bulletin, Vol.48, No.3, 291-298, 2002
The effect of hydrolytic degradation on the tensile properties of neat and reinforced Poly(p-dioxanone)
In this work a bioabsorbable Poly(p-dioxanone), PPDX, was mixed with 5 and 20% by weight Hydroxyapatite (HA) or Boron Nitride (BN). Pins of neat and filled PPDX were molded by a compression and transfer process. The pins were subjected to tensile testing before and after hydrolytic degradation. The hydrolysis was performed in vitro using a pH 7.4 phosphate buffer solution at 37 degreesC during 8 weeks. The use of 5% HA had almost no effect on the elastic modulus of PPDX, while 20% caused a slight reduction of this property. These results are probably related to poor dispersion and minor degradation of the matrix catalyzed by HA. Samples with HA were degraded much faster by hydrolysis than neat PPDX. On the other hand, the elastic modulus of PPDX was highly improved by the presence of BN, 5% of this compound increased its value from 35 MPa to 110 MPa, while 20% BN raised it to 160 MPa. Additionally, the value of the elastic modulus of PPDX/BN samples decreases with hydrolytic degradation time but is higher, after 8 weeks degradation, than that of neat PPDX. These are interesting results from the application point of view, since the reported values for the elastic modulus of the trabecular bone are in the range 50-100 MPa and therefore the BN filled PPDX may be useful for bone fixation implants.