This paper proposes a new approach to reference governor design. As in prior literature, the governor accepts input commands and modifies their evolution so that specified pointwise-in-time constraints on state and control variables are satisfied. The new approach applies to general discrete-time and continuous-time nonlinear systems with uncertainties. It relies on safety properties provided by sublevel sets of equilibria-parameterized functions. These functions need not be Lyapunov functions, and the corresponding sublevel sets need not be positively invariant. Technical conditions that capture the bare essentials of what is needed are identified and the usual desirable properties of reference governors are established. The new approach significantly broadens the class of methods available for constructing the nonlinear function that is required in the implementation of the reference governors. This advantage is illustrated in a nonlinear control problem where off-line, computer-based simulation is the basis for constructing the nonlinear function.