In medical treatment, a constant plasma concentration for an extended period of time is preferable for some diseases, while pulsatile delivery or delayed delivery is also required to avoid the tolerance and set a delayed time for medication. The dissolution-type TTS is expected to achieve pulsatile delivery. In this work, a mathematical model was proposed for the prediction of the plasma concentration-time profile following the application of the dissolution-type TTS. In vivo animal data was compared with the simulated profile together with the model parameters determined independently. The calculated concentration-time profile well agreed with the in vivo animal data.