Blends of amorphous poly(DL-lactide) (DL-PLA) and crystalline poly(L-lactide) (PLLA) with poly(methyl methacrylate) (PMMA) were prepared by both solution/precipitation and solution-casting film methods. The miscibility, crystallization behavior, and component interaction of these blends were examined by differential scanning calorimetry. Only one glass-transition temperature (T-g) was found in the DL-PLA/PMMA solution/precipitation blends, indicating miscibility in this system. Two isolated T-g's appeared in the DL-PLA/PMMA solution-casting film blends, suggesting two segregated phases in the blend system, but evidence showed that two components were partially miscible. In the PLLA/PMMA blend, the crystallization of PLLA was greatly restricted by amorphous PMMA. Once the thermal history of the blend was destroyed, PLLA and PMMA were miscible. The T-g composition relationship for both DL-PLA/PMMA and PLLA/PMMA miscible systems obeyed the Gordon-Taylor equation. Experiment results indicated that there is no more favorable trend of DL-PLA to form miscible blends with PMMA than PLLA when PLLA is in the amorphous state.