화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.11, No.1, 2-8, February, 2003
Export Citation
Preparation of Polymeric Self-Assembly and Its Application to Biomaterials
Chong-Su Cho†, In-Kyu Park, Jae-Woon Nah1, and Toshihiro Akaike2
  • School of Agricultural Biotechnology, Seoul National University, Suwon 441-744, Korea
  • 1Department of Polymer Science and Engineering, Sunchon National University, Sunchon 540-742, Korea
  • 2Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama 226-8501, Japan
E-mail:
The self-assembly of polymers can lead to supramolecular systems and is related to the their functions of material and life sciences. In this article, self-assembly of Langmuir-Blodgett (LB) films, polymer micelles, and polymeric nanoparticles, and their biomedical applications are described. LB surfaces with a well-ordered and layered structure adhered more cells including platelet, hepatocyte, and fibroblast than the cast surfaces with microphase-separated domains. Extensive morphologic changes were observed in LB surface-adhered cells compared to the cast films. Amphiphilic block copolymers, consisting of poly(γ-benzyl L-glutamate) (PBLG) as the hydrophobic part and poly(ethylene oxide) (PEO) [or poly(N-isopropylacrylamide) (PNIPAAm)] as the hydrophilic one, can self-assemble in water to form nanoparticles presumed to be composed of the hydrophilic shell and hydrophobic core. The release characteristics of hydrophobic drugs from these polymeric nanoparticles were dependent on the drug loading contents and chain length of the hydrophobic part of the copolymers. Achiral hydrophobic merocyanine dyes (MDs) were self-assembled in copolymeric nanoparticles, which provided a chiral microenvironment as redshifted aggregates, and the circular dichroism (CD) of MD was induced in the self-assembled copolymeric nanoparticles.
Keywords:self-assembly;Langmuir-Blodgett films;polymeric micelle;polymeric nanoparticles;induced circular dichroism
  1. Whitesides GM, Mathias JP, Seto CT, Science, 254, 1312 (1991) 
  2. Ringford H, Schlarb B, Venzmer J, Angew. Chem.-Int. Edit., 27, 113 (1988) 
  3. Blodgett KB, J. Am. Chem. Soc., 57, 1007 (1935) 
  4. Kuhn H, Mobius D, Bucher H, Techniques of Chemistry, A. Weissberger and B.W. Rossiter, Eds., Wiley, New York, Vol. 1, Part 3B (1973)
  5. Cho CS, Nagata R, Yagawa A, Takahashi S, Kunou M, Akaike T, J. Polym. Sci. C: Polym. Lett., 28, 89 (1990)
  6. Goupilk DW, Goodrich FC, J. Colloid Interface Sci., 62, 142 (1977) 
  7. Cho CS, Kim SW, Komoto T, Makromol. Chem., 191, 981 (1990) 
  8. Cho CS, Song SC, Kunou M, Akaike T, J. Colloid Interface Sci., 137, 292 (1990) 
  9. Cho CS, Kobayashi A, Goto M, Akaike T, Thin Solid Films, 264(1), 82 (1995) 
  10. Okano T, Kataoka K, Sakurai Y, Shimada M, Akaike T, Shinohara I, Artificial Org., 5, 468 (1981)
  11. Cho CS, Takayama T, Konou M, Akaike T, J. Biomed. Mater. Res., 24, 1369 (1990) 
  12. Cho CS, Kataoka T, Akiake T, J. Biomed. Mater. Res., 27, 199 (1993) 
  13. Cho CS, Kobayashi A, Goto M, Park KH, Akaike T, J. Biomed. Mater. Res., 32, 425 (1996) 
  14. Llanos GR, Sefton MV, J. Biomater. Sci.-Polym. Ed., 4, 381 (1993)
  15. Kobayashi A, Kobayashi K, Akaike T, J. Biomater. Sci.-Polym. Ed., 3, 499 (1992)
  16. Kobayashi A, Goto M, Kobayashi K, Akaike T, J. Biomater. Sci.-Polym. Ed., 6, 325 (1994)
  17. Cho CS, goto M, Kobayashi A, Kobayashi K, Akaike T, J. Biomater. Sci.-Polym. Ed., 7, 1097 (1996)
  18. Higuchi A, Tamiya S, Tsubomura T, Katoh A, Cho CS, Akaike T, Hara M, J. Biomater. Sci.-Polym. Ed., 11, 149 (2000) 
  19. Kunitake T, Angew. Chem.-Int. Edit., 31, 709 (1992) 
  20. Zhong XF, Varsheny SK, Eisenberg A, Macromolecules, 25, 7160 (1992) 
  21. Izzo D, Marque CM, Macromolecules, 26, 7189 (1993) 
  22. Kataoka K, Kwon GS, Yokohama M, Okano T, Sakurai Y, J. Control. Release, 24, 119 (1993) 
  23. Cheon JB, Jeong YI, Cho CS, Korea Polym. J., 6(1), 34 (1998)
  24. Jeong YI, Cheon JB, Kim SH, Nah JW, Lee YM, sung YK, Akaike T, Cho CS, J. Control. Release, 51, 169 (1998) 
  25. Nagarajan R, Ganesh K, J. Phys. Chem., 90, 5843 (1989) 
  26. Wilhelm M, Zhao CL, Wang Y, Xu R, Winnik MA, Mura JL, Riess G, Croucher MD, Macromolecules, 24, 1033 (1991) 
  27. Cho CS, Cheon JB, Jeong YI, Kim IS, Kim SH, Akaike T, Macromol. Rapid Commun., 18, 361 (1997) 
  28. Jeong YI, Nah JW, LEe HC, Kim SH, Cho CS, Int. J. Pharm., 188, 49 (1999) 
  29. Chung TW, Nah JW, Akaike T, Park YH, Cho CS, Polymer, 41(16), 6415 (2000) 
  30. Chung TW, Kim BJ, Park SY, Akaike T, Nah JW, Cho CS, Macromolecules, 33(24), 8921 (2000) 
  31. Hirano Y, Kawata J, Miura YF, Sugi M, Ishii T, Thin Solid Films, 327-329, 345 (1998)