The experimental and theoretical study was carried out for the adsorption of methylene chloride vapor on a activated carbon bed. A nonequilibrium, nonisothermal, and nonadiabatic mathematical model was developed to calculate the concentration and temperature profiles. A linear driving force mass-transfer model was found to be acceptable fit to the experimental data. The effects of operation variables, such as initial bed temperature, feed concentration etc., were investigated. Also, the effects of heat and mass transfer coefficients on the temperature and the concentration curve were studied. The overall heat transfer rate was controlled by the heat transfer between gas phase and bed wall. h_w, at unsteady state, while after reaching the steady state, heat transfer between wall and ambient, U_a, was rate controlling step. But the heat transfer coefficient between adsorbent and gas phase, h_s, had little effect on the temperature curves. It was also founded that mass transfer was limited by the surface diffusion. The cooling step followed by hot purge regeneration step in the TSA cycle might be omitted because the breakthrough curve of this system was not affected by the initial bed temperature.