Journal of Applied Polymer Science, Vol.89, No.12, 3371-3378, 2003
A combinatorial approach in designing hydrophilic surfaces for solid-phase peptide synthesis
A hydrophilic surface suitable for solid-state peptide synthesis was developed on a solid support called a lantern. The split-and-mix combinatorial technique was used to prepare about 500 surfaces in a very short time. Surfaces were analyzed according to values for gel formation, percentage weight grafted, grafted copolymer composition, and number of functional groups per lantern. These values were correlated to the purity of a peptide synthesized on these surfaces. (C) 2003 Wiley Periodicals, Inc.