Swelling Controlled Delivery of Antibiotic from a Hydrophilic Macromolecular Matrix with Hydrophobic Moieties

Sandeep Shukla; Anil Kumar Bajpai; Jaya Bajpai

Macromolecular Research, Vol.11, No.4, 273-282, August, 2003

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Swelling Controlled Delivery of Antibiotic from a Hydrophilic Macromolecular Matrix with Hydrophobic Moieties

Sandeep Shukla, Anil Kumar Bajpai^†, and Jaya Bajpai

Department of Chemistry, Government Autonomous Science College, Jabalpur (M.P.) - 482 001, India

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A hydrophilic macromolecular network containing hydrophobic moieties has been prepared by free radical copolymerization of acrylamide and styrene in the presence of poly(vinyl alcohol) (PVA) and its potential as controlled drug delivery carrier was evaluated with tetracycline as a model antibiotic drug. The amount of drug was assayed spectrophotometrically. The network was characterized by optical microscopy, infra-red spectroscopy and structural parameters such as average molecular weight between crosslinks (Mc), crosslink density (q) and number of elastically effective chains (Ve) were evaluated. It was found that with increasing concentration of PVA, ST and MBA in the hydrogel, the release rate initially increases but after definite concentrations of the above components the release rate falls. In the case of AM, release rate constantly decreases with increasing AM concentration in the hydrogel.

Keywords:hydrogel;poly(vinyl alcohol);swelling;release rate;kinetics

[References]

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Snowden MJ, Chowdhary BZ, Vincent B, Morris GE, J. Chem. Soc.-Faraday Trans., 92, 5013 (1996)
Bae YH, Okano T, Kim SW, J. Polym. Sci. B: Polym. Phys., 28, 923 (1990)
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Kengy ER, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C38, 365 (1998)
Cleland JL, Sanders LM, Hendren RW, Pharmaceutical Biotechnology, Protein Delivery, Physical Systems, Plenum Press, New York, Vol. 10, p. 1-43 (1997)
Palmer RM, Watts TLP, Wilson RF, J. Clin. Periodont., 23, 670 (1996)
Bruch SD, Controlled Drug Delivery, CRC Press, Boca Raton, FLA, Vol. I & II (1983)
Snell FD, Snell CT, Colorimetric Methods of Analysis, Van Nostrand Reinhold Co., Vol. VI AAA (1971)
Peppas NA, Franson NM, J. Polym. Sci. B: Polym. Phys., 21, 983 (1983)
Krosmeyer RW, Peppas NA, J. Membr. Sci., 9, 211 (1981)
Reinhart CI, Peppas NA, J. Membr. Sci., 18, 227 (1984)
Ding ZY, Akinois JJ, Saloyev R, J. Polym. Sci. B: Polym. Phys., 20, 1035 (1991)
Rosiak J, Burczak K, Czokynoka T, Pekala W, Radiat. Phys. Chem., 22, 917 (1983)
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Colombo P, Gazzaniga A, Conte U, Sangalli ME, Manna AL, Proc. Int. Symp. Control Release Bioact Mater., 14, 83 (1987)
Davison GR, Peppas NA, J. Control. Release, 3, 243 (1986)
Grinsted RA, Clark L, Koenig JL, Macromolecules, 25, 1235 (1992)
Kim SW, Bae YH, Okano T, Pharm. Res., 9, 283 (1992)
Peppas NA, Khare AR, Adv. Drug Deliv. Rev., 11, 1 (1993)
Xu C, Sunada H, Chem. Pharm. Bull., 43, 483 (1995)
Shah SS, Kulkarni MG, Mashelkar RA, J. Appl. Polym. Sci., 41, 2437 (1990)
McNeill ME, Graham NB, J. Biomater. Sci.-Polym. Ed., 4, 305 (1993)
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[Referenced By]

[1] Chen G, Hoffman AS, Nature, 49, 373 (1995)

[2] Snowden MJ, Chowdhary BZ, Vincent B, Morris GE, J. Chem. Soc.-Faraday Trans., 92, 5013 (1996)

[3] Bae YH, Okano T, Kim SW, J. Polym. Sci. B: Polym. Phys., 28, 923 (1990)

[4] Siegel RA, Firestone BA, Macromolecules, 21, 3294 (1988)

[5] Kajwara K, Rossurphy SB, Nature, 355, 208 (1992)

[6] Paul W, Sharma CP, J. Appl. Polym. Sci., 57(12), 1447 (1995)

[7] Peppas NA, Curr. Opin. Colloid Interface Sci., 2, 531 (1997)

[8] Atkins TW, Peacock SJ, J. Microencapsul., 13, 709 (1997)

[9] Kengy ER, J. Macromol. Sci.-Rev. Macromol. Chem. Phys., C38, 365 (1998)

[10] Cleland JL, Sanders LM, Hendren RW, Pharmaceutical Biotechnology, Protein Delivery, Physical Systems, Plenum Press, New York, Vol. 10, p. 1-43 (1997)

[11] Palmer RM, Watts TLP, Wilson RF, J. Clin. Periodont., 23, 670 (1996)

[12] Bruch SD, Controlled Drug Delivery, CRC Press, Boca Raton, FLA, Vol. I & II (1983)

[13] Snell FD, Snell CT, Colorimetric Methods of Analysis, Van Nostrand Reinhold Co., Vol. VI AAA (1971)

[14] Peppas NA, Franson NM, J. Polym. Sci. B: Polym. Phys., 21, 983 (1983)

[15] Krosmeyer RW, Peppas NA, J. Membr. Sci., 9, 211 (1981)

[16] Reinhart CI, Peppas NA, J. Membr. Sci., 18, 227 (1984)

[17] Ding ZY, Akinois JJ, Saloyev R, J. Polym. Sci. B: Polym. Phys., 20, 1035 (1991)

[18] Rosiak J, Burczak K, Czokynoka T, Pekala W, Radiat. Phys. Chem., 22, 917 (1983)

[19] Hooper HH, Baker JP, Blanch HW, Prausnitz JM, Macromolecules, 23, 1096 (1983)

[20] Peppas NA, Pharm. Acta Helv., 60, 110 (1985)

[21] Colombo P, Gazzaniga A, Conte U, Sangalli ME, Manna AL, Proc. Int. Symp. Control Release Bioact Mater., 14, 83 (1987)

[22] Davison GR, Peppas NA, J. Control. Release, 3, 243 (1986)

[23] Grinsted RA, Clark L, Koenig JL, Macromolecules, 25, 1235 (1992)

[24] Kim SW, Bae YH, Okano T, Pharm. Res., 9, 283 (1992)

[25] Peppas NA, Khare AR, Adv. Drug Deliv. Rev., 11, 1 (1993)

[26] Xu C, Sunada H, Chem. Pharm. Bull., 43, 483 (1995)

[27] Shah SS, Kulkarni MG, Mashelkar RA, J. Appl. Polym. Sci., 41, 2437 (1990)

[28] McNeill ME, Graham NB, J. Biomater. Sci.-Polym. Ed., 4, 305 (1993)

[29] McNeill ME, Graham NB, J. Biomater. Sci.-Polym. Ed., 5, 111 (1993)