Cyclotrimerization of acetylene to benzene was investigated on Pd/titania as a means to utilize acetylene as the feedstock for synthesis of valuable hydrocarbons. Literature indicated Pd and titania possess the activity for the reaction with relation to the density of Pd (111) plane and reduced titanium ions. Study of catalytic activity, product selectivity, and catalyst stability under varying catalyst specification and reaction condition has to be further conducted to develop a competitive process for the reaction. Our research investigated the effect of Pd loading, additional metal oxide, and reduction treatment upon the catalytic behavior of Pd/titania for the reaction in the laboratory scale.