Inorganic Chemistry, Vol.42, No.13, 4102-4108, 2003
Ruthenium(III) triazacyclononane dithiocarbamate, pyridinecarboxylate, or aminocarboxylate complexes as scavengers of nitric oxide
The preparation of a series of [Ru-III(tacn)(eta(2)-dtc)(eta(1)-dtc)][PF6] (tacn = 1,4,7-triazacyclononane; dtc = dimethyl-dithiocarbamate, diethyldithiocarbamate, pyrrolidinedithiocarbamate, L-prolinedithiocarbamate, L-prolinemethyl ester dithiocarbamate, L-N-methylisoleucinedithiocarbamate) complexes, 5-11, is described. Complex 5 reacts with NO to form the ruthenium nitrosyl complex 12. A series of [Ru-III(tacn)(pyc)Cl][PF6] (pyc = 2-pyridinecarboxylic acid, 2,4- and 2,6-pyridinecarboxylic acid) complexes, 14-16, were prepared along with [Ru-III(tacn)(mida)][PF6] (mida = N-methyliminodiacetic acid), 13, and [Ru-III(Hnota)Cl], 17, (Hnota = 1-acetic acid-4,7-bismethylcarboxylate-1,4,7-triazacyclononane). Complexes 5-17 were evaluated for use as NO scavengers in an in vitro assay using RAW264 murine macrophage cells. [Ru-III(tac(n))(eta(2)-dtc)(eta(1)-dtc)][PF6] complexes 5-11 are very efficient NO scavengers in this assay.