A new kind of nano-composite of nano-hydroxyapatite (n-HA) and polyamide(8063) (PA) was prepared directly using nano-hydroxyapatite slurry and co-solution method under normal atmospheric pressure. The results show that the n-HA content in the composite can reach 65 wt%, similar to the apatite content in natural bone. Interface chemical bonding forms between n-HA and polyamide, the n-HA keeps the original morphological structure with a crystal size of 10-30 nm in diameter by 50-90 nm in length with an aspect ratio of 2.5, and distributes uniformly in the composite. The synthetic nano-composite could be one of the best bioactive materials for load-bearing bone repair or substitution. (C) 2003 Kluwer Academic Publishers.