In this contribution a novel atmospheric pressure SF6-cold-plasma method is suggested for the conversion of cellophane surfaces into perfluorinated layers. This approach takes advantage of the efficiency of SFx (x<6) species generated in the discharge for oxygen extraction, dehydro-fluorination and fluorination reaction mechanisms. It was shown that relative surface atomic concentrations as high as 58% can be created under relatively short treatment times (5 minutes), and that CF2 groups are the dominant components of the plasma-generated surface layers. Surface morphology analysis by atomic force microscopy (AFM) and scanning electron microscopy (SEM) indicate that SF6-discharge environments selectively interact with the amorphous and crystalline zones of cellulose. Contact angle evaluations of plasma-exposed cellophane surfaces show an intense hydrophobic character, with contact angles as high as 120&DEG;. Potential applications of perfluorinated cellophane layers are suggested.