Different amounts of two skin permeation enhancers, Oleic acid (OA) and Propylene glycol (PG), were mixed thoroughly with solution of a commercial acrylic pressure sensitive adhesive (Duro-Tak). Films with different adhesive layer thickness (30 and 60 mum) were prepared by casting of formulations with a film applicator on a PET 80-mum film and drying of solvents. Peel test was done on different formulations according to ASTM D3330. Surface study and thermal analysis were used for explaining the results. It was shown that the effect of interfacial work of adhesion on peel strength was too low to be considered. PG had no significant effect on peel strength, which was related to effect of hydrogen bonds between PG and copolymer chains acting as crosslinks. CA decreased peel strength significantly, which is due to important changes in copolymer structure. These changes can be found by relatively sharp drop in T-g values. Adhesive-cohesive transition occurred in OA formulations as a result of OA crystals formation. CA migration to surface in concentrations of more than 10 (w/w %) was confirmed by results of DSC and surface study. In contrast with PG, doubling of thickness had no effect on peel strength. (C) 2003 Wiley Periodicals, Inc.