화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.28, No.2, 103-110, March, 2004
Export Citation
토코페롤을 함유하는 생분해성 폴리(ε-카프로락톤) 마이크로캡슐의 제조 및 방출 특성
Preparation and Release Characterization of Biodegradable Poly(ε-caprolactone) Microcapsules Containing Tocopherol
박수진†, 김기석, 민병각1, 홍성권2
  • 한국화학연구원 화학소재연구부
  • 1충주대학교 고분자공학과
  • 2충남대학교 고분자공학과
Soo-Jin Park†, Ki-Seok Kim, Byung-Gak Min1, and Sung-Kwon Hong2
  • Advanced Materials Division, Korea Research Institute of Chemical Technology, P. O. Box 107, Yusong, Daejeon 305-600, Korea
  • 1Polymer Science and Engineering, Chungju National University, Iryu Myon, Chungju 380-702, Korea
  • 2Polymer Science and Engineering, Chungnam National University, Gung-dong, Yusung, Daejeon 305-764, Korea
E-mail:
초록
토코페롤을 함유하는 폴리(ε-카프로락톤)(PCL) 마이크로캡슐은 액중건조법에 의하여 제조하였고, 제조 조건에 따른 마이크로캡슐의 특성과 PCL 필름을 사용하여 PCL의 분해거동을 측정하였다. 제조된 마이크로캡슐의 크기 및 형태와 구조적 특성은 각각 SEM과 XRD를 이용하여 관찰하였다. 또한, 접촉각 측정을 통하여 심물질의 농도에 따른 마이크로캡슐의 표면자유에너지를 측정하였다. 실험결과, 마이크로캡슐은 유화제로 폴리(비닐 알코올)을 사용한 경우 안정된 구형의 마이크로캡슐이 형성되었고, 마이크로캡슐의 표면자유에너지와 PCL의 결정성은 감소하고, PCL 필름은 약 21일 후 분해가 시작되었다. 토코페롤의 방출특성은 UV/vis.에 의하여 측정하였으며, 마이크로캡슐의 방출속도는 교반속도의 증가와 함께 증가하였다. 이는 교반속도의 증가와 함께 감소된 마이크로캡슐 입자 크기에 의한 방출용액과 마이크로캡슐 사이의 계면의 증가에 의한 것으로 판단된다.
The biodegradable poly(ε-caprolactone) (PCL) microcapsules containing tocopherol were prepared by oil-in-water emulsion solvent evaporation method. The features of the microcapsules were investigated in the manufacturing conditions and degradation behaviors. The form and structural feature of the microcapsules were measured by scanning electron microscope and X-ray diffraction, respectively. The surface free energy of the microcapsules was executed using contact angle measurement. As a result, the microcapsules were more stable and spherical with poly(vinyl alcohol) given in a surfactant. The surface free energy and crystallinity of microcapsules were decreased with increasing the core concentration, and degradation of PCL was occurred after 21 days. The release behaviors were examined by UV/vis. spectrophotometer. It was found that the release rate of the microcapsules was increased with increasing the stirring rate, due to the increased interface between microcapsules and release media.
Keywords:microcapsule;poly(ε-caprolactone);tocopherol;surface free energy;release behaviors
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