Hydrogen-bonded two-dimensional networks of 1,3,5-tris(10-carboxydecyloxy) benzene (TCDB) were formed on the surface of highly oriented pyrolytic graphite (HOPG). With these networks as host networks and copper(II) phthalocyanine (CuPc) and coronene as guest molecules, the host-guest architectures of CuPc/TCDB and coronene/TCDB were achieved when host and guest molecules coadsorb on HOPG. The monolayer structure of the networks of TCDB and the inclusion structures of host-guest systems were investigated by STM.