The real-time implementation of a set of multi-linear model-based control design methodologies is studied using a bench-scale pH neutralization system that exhibits nonlinear dynamics. It is envisaged that advanced model-based control strategy based on the multi-linear models presents a promising paradigm to design controllers for complex nonlinear plants. The multi-linear modeling philosophy is based on the selection of a set of linear models, complemented with an adaptation mechanism to explain the nonlinear plant behavior in the whole operating range. Practical implications of each control strategy are evaluated and discussed. (C) 2003 Published by Elsevier Ltd.