Tomato skins and their mixtures with seeds were submitted to supercritical CO2 extraction using a flow apparatus at pressures of 250 and 300 bar and temperatures of 60 and 80 degreesC. Two different mean particle sizes (80 and 345 mum) were used at two solvent flow rates (0.792 and 1.35 kg/h). The yields of lipids, lycopene, and beta-carotene obtained by supercritical fluid extraction were compared with those obtained by conventional organic solvent extraction. Supercritical fluid extraction from tomato skins at 300 bar and 80 degreesC allowed the recovery of 80% of the lycopene and 88% of the beta-carotene, using about 130 g Of CO2 per gram of matrix at the lower flow rate Of CO2.