Copper indomethacin (Cu-Indo) is a nonsteroidal anti-inflammatory drug currently available for veterinary use. Its application is limited to oral formulations because of its poor solubility in biocompatible solvents. In this study, Cu-Indo has been coprecipitated with poly(vinylpyrrolidone) (PVP) to increase the solubility of Cu-Indo in biocompatible solvents. The aerosol solvent extraction system was used to produce Cu-Indo/PVP coprecipitates in various ratios. Carbon dioxide was used as an antisolvent to precipitate PVP and Cu-Indo from dimethylformamide solutions. Microspheres of PVP and Cu-Indo were formed that ranged in size from 50 nm to 4 mum at most conditions studied. A coprecipitate containing 10 wt % Cu-Indo and 90 wt % PVP was found to be at least 93 times more soluble in ethanol than factory-grade Cu-Indo. The significance of these results is that there may now be the potential for Cu-Indo to be used in parenteral applications.