Synthesis and Polymerization of Methacryloyl-PEG-Sulfonic Acid as a Functional Macromer for Biocompatible Polymeric Surfaces

Jun-Guk Kim; Sang Jun Sim; Ji-Heung Kim; Soo Hyun Kim; Young Ha Kim

Macromolecular Research, Vol.12, No.4, 379-383, August, 2004

Jun-Guk Kim, Sang Jun Sim , Ji-Heung Kim^†, Soo Hyun Kim¹, and Young Ha Kim¹

Department of Chemical Engineering, Sungkyunkwan University, Suwon, Gyonggi 440-746, Korea
¹Biomaterials Research Center, Korea Institute of Science and Technology, P. O. Box 131, Cheongryang, Seoul 130-650, Korea

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Poly(ethylene glycol)s (PEGs) are unique in their material properties, such as biocompatibility, non-toxicity, and water-solublizing ability, which are extremely useful for a variety of biomedical applications. In addition, a variety of functional PEGs with specific functionality at one or both chain ends have been synthesized for many specialized applications. Surface modifications using PEG have been demonstrated to decrease protein adsorption and platelet or cell adhesion on biomaterials. Furthermore, PEGs having anionic sulfonate terminal units have been proven to enhance the blood compatibility of materials, which has been demonstrated by the negative cilia concept. The preparation of telechelic PEGs having a sulfonic acid group at one end and a polymerizable methacryloyl group at the other is an interesting undertaking for providing macromers that can be used in various vinyl copolymerization and gel systems. In this paper, preliminary results on the synthesis and polymerization behavior of a novel PEG macromer is described with the aim of identifying a biocompatible material for applications in various blood-contacting devices.

Keywords:biomaterials;blood-compatibiltity;surface modification;PEG macromer;methacryloyl group

[References]

Inoue H, Fijimoto K, Uyama Y, Ikada Y, J. Biomed. Mater. Res., 35, 255 (1997)
Klement P, Du YJ, Berry L, Andrew M, Chan AKC, Biomaterials, 23, 527 (2002)
Guo SR, Shen LJ, Feng LX, Polymer, 42(3), 1017 (2001)
Lee SH, Kim SH, Kim YH, Han YK, Macromol. Res., 10(2), 85 (2002)
Srinivasan S, Sawyer PN, in Biomedical Polymers, A. Rembaum and M. Shen, Eds., New York, Marcel Dekker, 51 (1971)
Ishihara K, Fujita H, Yoneyama T, Iwasaki Y, J. Biomater. Sci.-Polym. Ed., 11, 1183 (2000)
Han DK, Park KD, Ryu GH, Kim UY, Min BG, Kim YH, J. Biomed. Mater. Res., 24, 2213 (2003)
Wise DL, Trantolo DJ, Altobelli DE, Yaszemski MJ, Encyclopedic Handbook of Biomaterials and Bioengineering, New York, Marcel Dekker, 2, 1071 (1995)
Han DK, Park KD, Kim YH, J. Biomater. Sci.-Polym. Ed., 9, 164 (1998)
Maiti S, Chatterji PR, Nisha CK, Manorama SV, Aswal VK, Goyal PS, J. Colloid Interface Sci., 240(2), 630 (2001)

[Referenced By]

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[1] Inoue H, Fijimoto K, Uyama Y, Ikada Y, J. Biomed. Mater. Res., 35, 255 (1997)

[2] Klement P, Du YJ, Berry L, Andrew M, Chan AKC, Biomaterials, 23, 527 (2002)

[3] Guo SR, Shen LJ, Feng LX, Polymer, 42(3), 1017 (2001)

[4] Lee SH, Kim SH, Kim YH, Han YK, Macromol. Res., 10(2), 85 (2002)

[5] Srinivasan S, Sawyer PN, in Biomedical Polymers, A. Rembaum and M. Shen, Eds., New York, Marcel Dekker, 51 (1971)

[6] Ishihara K, Fujita H, Yoneyama T, Iwasaki Y, J. Biomater. Sci.-Polym. Ed., 11, 1183 (2000)

[7] Han DK, Park KD, Ryu GH, Kim UY, Min BG, Kim YH, J. Biomed. Mater. Res., 24, 2213 (2003)

[8] Wise DL, Trantolo DJ, Altobelli DE, Yaszemski MJ, Encyclopedic Handbook of Biomaterials and Bioengineering, New York, Marcel Dekker, 2, 1071 (1995)

[9] Han DK, Park KD, Kim YH, J. Biomater. Sci.-Polym. Ed., 9, 164 (1998)

[10] Maiti S, Chatterji PR, Nisha CK, Manorama SV, Aswal VK, Goyal PS, J. Colloid Interface Sci., 240(2), 630 (2001)