용융 압출 발표에 의한 폴리락틱산 지지체 가공

이종록; 강호종; Jong Rok Lee; Ho-Jong Kang

Polymer(Korea), Vol.29, No.2, 198-203, March, 2005

Export Citation

용융 압출 발표에 의한 폴리락틱산 지지체 가공

Preparation of Poly(L-lactic acid) Scaffolds by Melt Extrusion Foaming

이종록, 강호종 ^†

기능성 고분자 신소재 연구센터, 단국대학교 고분자공학과

Jong Rok Lee, and Ho-Jong Kang^†

Center for Advanced Functional Polymers,Dept. of Polymer Sci. and Eng., Dankook University, #8 Hannam-dong, Yongsan-ku, Seoul 140-714, Korea

E-mail:

초록

용융 압출 발표에 의하여 폴리락틱산(PLLA) 지지체를 제조하고 발포 조건이 지지체의 구조와 기계적 특성에 미치는 영향을 살펴보고 이를 염 추출법에 의하여 제조된 지지체와 비교하였다. 발포제를 함유한 PLLA 용융체가 압출기 및 다이에서 체류하는 시간이 발포제의 무게를 최대로 감소시키는 시간과 일치하여야 최적의 PLLA 지지체의 구조를 얻을 수 있음을 확인하였다. PLLA 지지체의 구조를 유지하기 위해서는 발포제의 함량을 10 wt% 이하로 조절해야 하며 PLLA 지지체의 다공도는 PLLA의 압출기에서의 체류시간에 가장 큰 영향을 받음을 알 수 있었다. 용융 압출 발포에 의하여 얻어진 지지체는 일반적으로 염 추출법에 의하여 제조된 지지체보다 다소 낮은 다공도를 갖지만 발포 조건의 조절에 의하여 적절한 다공 크기와 다공의 연결성을 가지며 동시에 우수한 기계적 특성을 가져 경조직 재생(hard tissue regeneration)용으로 사용이 가능할 것으로 사료된다.

Melt extrusion foaming process for the preparation of poly(L-lactic acid) (PLLA) scaffolds was carried out and the effects of foaming conditions on the pore structure of PLLA scaffolds and their mechanical properties were investigated. The porosity and mechanical properties of fabricated scaffolds were compared with the scaffolds obtained from the salt leaching method as well. It was found that the optimum pore structure was achieved when the PLLA melt was kept in extruder for the maximum decomposition time of blowing agent. In order to maintain the proper scaffolds structure, the blowing agent content should be less than 10 wt%. It can be concluded that melt extrusion foaming process allows for the production of scaffold having higher mechanical properties with reasonable pore size and open cell structure for hard tissue regeneration even though it has less poresity than scaffolds made by salt leaching process.

Keywords:biodegradable polymers;poly(L-lactic acid);scaffolds;melt extrusion foaming;blowing agent

[References]

Hutmacher DW, Biotechnology, 12, 689 (1994)
Langer R, Vacanti JP, Science, 260, 920 (1993)
Cima LG, Vacanti JP, Ingber D, Mooney D, Langer R, J. Biomech. Eng., 113, 143 (1991)
Wise DL, Biopolymeric Controlled System, Vol. 1, CRS Press, Boca Raton, Ch. 8 (1985)
Bae Y, Cima LG, Ingber D, Vacanti JP, Langer R, J. Biomed. Mater. Res., 27, 183 (1993)
Gogolewski S, Pennings AJ, Colloid Polym. Sci., 261, 477 (1983)
Mikos AG, Sarakinos AJ, Leite SM, Vacanti JP, Langer R, Biomaterials, 14, 323 (1993)
Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP, Polymer, 35(5), 1068 (1994)
Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos A, Langer R, J. Biomed. Mater. Res., 11, 27 (1993)
Nam YS, Park TG, Biomaterials, 20, 1783 (1999)
Harris LD, Kim BS, Mooney DJ, J. Biomed. Mater. Res., 42, 396 (1998)
Whang K, Thomas CH, Healy KE, Nuber G, Polymer, 36(4), 837 (1995)
Andriano KP, Tabata Y, Ikada Y, Heller Y, J. Biomed. Mater. Res., 48, 602 (1999)
Park A, Wu B, Griffith LG, J. Biomater. Sci.-Polym. Ed., 9, 89 (1998)
Hayashi T, Prog. Polym. Sci, 19, 663 (1994)
Andriano KP, Pohojonen T, Tormala P, J. Appl. Biomater., 5, 133 (1994)
Agrawal CM, Niederauer GG, Athanasiou KA, Tissue Eng., 1, 24 (1995)
Gomes ME, Ribeiro AS, Malafaya PB, Reis RL, Cunha AM, Biomaterials, 22, 883 (2001)
Salgado AJ, Gomes ME, Chou A, Coutinho OP, Reis RL, Hutmacher DW, Mater. Sci. Eng., C20, 27 (2002)
Gomes ME, Godinho JS, Tchalamov D, Cunha AM, Reis RL, Mater. Sci. Eng., C20, 19 (2002)
Mano JF, Vaz CM, Mendes SC, Reis RL, Cunha AM, J. Mater. Sci. -Mater. Med., 10, 857 (1999)
Thomson RC, Yaszemski MJ, Powers JM, Mikos AG, J. Biomater. Sci.-Polym. Ed., 7, 23 (1995)

[Related Articles]

[1] Hutmacher DW, Biotechnology, 12, 689 (1994)

[2] Langer R, Vacanti JP, Science, 260, 920 (1993)

[3] Cima LG, Vacanti JP, Ingber D, Mooney D, Langer R, J. Biomech. Eng., 113, 143 (1991)

[4] Wise DL, Biopolymeric Controlled System, Vol. 1, CRS Press, Boca Raton, Ch. 8 (1985)

[5] Bae Y, Cima LG, Ingber D, Vacanti JP, Langer R, J. Biomed. Mater. Res., 27, 183 (1993)

[6] Gogolewski S, Pennings AJ, Colloid Polym. Sci., 261, 477 (1983)

[7] Mikos AG, Sarakinos AJ, Leite SM, Vacanti JP, Langer R, Biomaterials, 14, 323 (1993)

[8] Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP, Polymer, 35(5), 1068 (1994)

[9] Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos A, Langer R, J. Biomed. Mater. Res., 11, 27 (1993)

[10] Nam YS, Park TG, Biomaterials, 20, 1783 (1999)

[11] Harris LD, Kim BS, Mooney DJ, J. Biomed. Mater. Res., 42, 396 (1998)

[12] Whang K, Thomas CH, Healy KE, Nuber G, Polymer, 36(4), 837 (1995)

[13] Andriano KP, Tabata Y, Ikada Y, Heller Y, J. Biomed. Mater. Res., 48, 602 (1999)

[14] Park A, Wu B, Griffith LG, J. Biomater. Sci.-Polym. Ed., 9, 89 (1998)

[15] Hayashi T, Prog. Polym. Sci, 19, 663 (1994)

[16] Andriano KP, Pohojonen T, Tormala P, J. Appl. Biomater., 5, 133 (1994)

[17] Agrawal CM, Niederauer GG, Athanasiou KA, Tissue Eng., 1, 24 (1995)

[18] Gomes ME, Ribeiro AS, Malafaya PB, Reis RL, Cunha AM, Biomaterials, 22, 883 (2001)

[19] Salgado AJ, Gomes ME, Chou A, Coutinho OP, Reis RL, Hutmacher DW, Mater. Sci. Eng., C20, 27 (2002)

[20] Gomes ME, Godinho JS, Tchalamov D, Cunha AM, Reis RL, Mater. Sci. Eng., C20, 19 (2002)

[21] Mano JF, Vaz CM, Mendes SC, Reis RL, Cunha AM, J. Mater. Sci. -Mater. Med., 10, 857 (1999)

[22] Thomson RC, Yaszemski MJ, Powers JM, Mikos AG, J. Biomater. Sci.-Polym. Ed., 7, 23 (1995)