Catalysts based on a physical mixture of Ga2O3 and MoO3 have been prepared and evaluated for propane partial oxidation to propene. The Ga2O3/MoO3 catalysts demonstrated propene yields greater than a 6 wt% V2O5/TiO2 catalyst, which is known to be active for the reaction. The higher yield of propene was achieved by the alkane activation properties of Ga2O3 and the selective oxidation function of MoO3 combining in a synergistic manner.