Journal of Bioscience and Bioengineering, Vol.96, No.6, 585-587, 2003
Electrical communication between NAD-dependent enzyme and metal electrode using ferrocene-labeled NAD derivatives
The target N-6-ferrocene substituted NAD derivatives (ferrocene-labeled NAD, Fc-NAD) were synthesized as an electron-relay NAD cofactor. The synthesized NAD derivatives possessed some biological activites as substrates in the alcohol dehydrogenase systems. The oxidation current depended on both addition of ethanol and spacer length of Fc-NAD.
Keywords:NAD-dependent enzyme;ferrocene-labeled NAD (Fc-NAD);cyclic voltammogram;mediator;alcohol dehydrogenase (ADH)