The results of simulations of direct concentration control of a distillation column in industrial scale are presented. Both controlled variables, the two product concentrations, are determined by on-line gas chromatographs and are characterised by high dead times of about 30 min. For the resulting scanning control of the product concentrations corresponding decentralised PI controllers were developed and applied. The control of the product concentrations developed presents a conventional DV structure and was exemplarily tested for disturbances in feed flow and feed concentrations. The calculations carried out exhibit a good time behaviour of the whole system. On this occasion it can be stated that the control quality could be clearly improved if a steady-state decoupling by output transformation was employed. In this case the results achieved are totally comparable to those of internal model control (IMC), which was in use at the production plant for over two years.