The hydrothermal reaction of mellitic acid, 4,4'-bipydine, and Cu-(CH3COO)(2).H2O gave rise to a novel 3D supramolecular architecture interpenetrated by three types of coordination polymer motifs. Two independent {[CU2(mellitate)(4,4'-bpy)(H2O)(2)](2-)} 3D polymers incorporating helical substructures were interwoven into a 3D network with double-stranded helical tubes that host 1D linear polymers [Cu(4,4'-bpy)(H2O)4](2+)}(n).