Various kinetic models proposed for the synthesis of TAME (tert-amyl methyl ether, 2-methoxy-2-methyllbutane) were tested against experimental batch reactor data. The experiments were carried out with methanol/isoamylenes molar ratios varying from 0.2 to 2.0 at temperatures between 333 and 353 K. The range of validity of the various models was evaluated by simulating the experimental conditions and by comparing the adequacy of the models to predict the experimental changes of composition as a function of the catalyst contact time and composition at reaction equilibrium. Activity-bared models were found to predict the experimental results better within a wider range of conditions than the concentration-based models, The activity-based models were additionally compared by estimating the values for the model parameters from the experimental data.