Microarray technology has come of age for use in high-throughput operations and large-scale studies. It allows rapid and simultaneous detection Of thousands of parameters within a single experiment. Recent developments in the field of carbohydrate microarray technology facilitate applications for different types of protein-carbohydrate interactions. These developments included capture molecule immobilization, surface engineering and detection strategies to analyze entire glycomes and glycosylation in vertebrate systems, the most common post-translational modification.