Experimental results for isothermal Newtonian flow through a high porosity anisotropic porous medium are provided. The porous medium is formed by a knitted stainless steel wire mesh rolled up to form a cylindrical plug. This kind of porous medium is generally used as a mist eliminator in the chemical and petroleum industries. Experimental results are compared with pressure drop predictions obtained with a theoretical pore-scale method. The model allows for anisotropy and is applied predictively over both the Darcy and non-Darcy regimes, requiring only that the porosity, dimensions of the wire and characteristic lengths of the plug be known. The predictions compare reasonably well with the experimental results.