A nonlinear internal model control (NIMC) strategy based on automatically configuring radial basis function networks (RBFN) is proposed for single-input single-output (SISO) systems of relative degree greater than unity. The automatic configuration and training of the RBFN is carried out employing hierarchically-self-organizing-learning algorithm, which eliminates a predefined network structure, with closed-loop input-output data generated for a series of setpoint changes using PI controller. Simulation studies with automatically configuring RBFN for isothermal polymerization reactor control demonstrate the superior performance of the proposed control strategy with automatically configuring RBFN over PI control for setpoint tracking as well as disturbance rejection.