As a part of our ongoing research program on the PVTx measurements by the Burnett method for HFC + hydrocarbon and/or inorganic compound systems, in this work the experimental results for the nitrous oxide (N2O) + fluoromethane (R41) system will be described. The system was chosen as an alternative refrigerant mixture. The thermodynamic properties of both mixture constituents are well known from the literature, but no experimental results have been published so far on the PVTx properties of this specific binary system. PVTx measurements were performed for the binary N2O + R41 system for four isotherms (283, 303, 323 and 343 K). In total, 17 runs were performed in a pressure range from 4600 to 150 kPa. The second and third virial coefficients along with the second and third cross-virial coefficients were derived from experimental results. The experimental uncertainty in second and third virial coefficients is estimated to be within +/- 2 cm(3)/mol and 500 cm(6)/mol(2), respectively. (c) 2004 Elsevier B.V. All rights reserved.