Model predictive control (MPC) provides a natural framework to realize feedforward and feedback control for nonlinear systems where the effect of disturbances (DVs) cannot be separated from that of manipulated variables (MVs). This study examines the performance of MPC with measured DVs as partial inputs of the model used, which is termed as combined feedforward/ feedback MPC (CMPC) in contrast to conventional MPC using a model without input of any measured DV. In the simulation of a pH process, we demonstrate the clear superiority of CMPC over MPC. In the experiment with a bench-scale ethanol and water distillation column, CMPC and MPC using artificial neural network (ANN) models are applied to the dual temperature control problem. External recurrent neural networks (ERNs) with and without a measured DV (feed rate of the column) as their partial input are built and employed in the experiment, with a result that inclusion of the measured DV in the model makes CMPC perform significantly better than MPC. To strengthen practical experience in applying ANN-based MPC, a detailed procedure of the experiment is also documented.