The reactions of OH + HBr and all isotopic variants have been measured in a pulsed supersonic Laval nozzle flow reactor between 53 and 135 K, using a pulsed DC discharge to create the radical species and laser induced fluorescence on the A (2)Sigma <- X (2)Pi (v' = 1 <- v" = 0) transition. All reactions are found to possess an inverse temperature dependence, in accord with previous work, and are fit to the form k = A(T/298)(-n), with k(1) (OH + HBr) = (10.84 +/- 0.31) x 10(-12)(T/298)((-0.67 +/- 0.02)) cm(3)/s, k(2) (OD + HBr) = (6.43 +/-2.60) x 10(-12)(T/298)((-1.19 +/- 0.26)) cm(3)/s, k(3) (OH + DBr) = (5.89 +/- 1.93) x 10(-12)(T/298)((-0.76 +/- 0.22)) cm(3)/s, and k(4) (OD + DBr) = (4.71 +/- 1.56) x 10(-12) (T/298)((-1.09 +/- 0.21)) cm(3)/s. A global fit of k vs T over the temperature range 23-360 K, including the new OH + HBr data, yields k(T) = (1.06 +/- 0.02) x 10(-11)(T/298)((-0.90 +/- 0.11)) cm(3)/s, and (0.96 +/- 0.02) x 10(-11)(T/298)((-0.90 +/- 0.03)) exp(((-2.88 +/- 1.82 K)/T)) cm(3)/s, in accord with previous fits. In addition, the primary and secondary kinetic isotope effects are found to be independent of temperature within experimental error over the range investigated and take on the value of (k(H)/k(D))(AVG) = 1.64 for the primary effect and (k(H)/k(D))(AVG) = 0.87 for the secondary effect. These results are discussed within the context of cur-rent experimental and theoretical work.