Enhancement of Oxygen Transfer in Hollow Fiber Membrane by the Vibration Method

Gi-Beum Kim; Seong-Jong Kim; Chul-Un Hong; Tae-Kyu Kwon; Nam-Gyun Kim

Korean Journal of Chemical Engineering, Vol.22, No.4, 521-527, July, 2005

DOI10.1007/BF02706636 Export Citation

Enhancement of Oxygen Transfer in Hollow Fiber Membrane by the Vibration Method

Gi-Beum Kim^†, Seong-Jong Kim¹, Chul-Un Hong, Tae-Kyu Kwon, and Nam-Gyun Kim

Division of Bionics and Bioinformatics, College of Engineering, Chonbuk National University, 664-14 1ga, Duckjin-dong, Duckjin-gu, Jeonju 561-756, Korea
¹Dept. of Applied Materials Engineering, Iksan National College, 194-5, Ma-dong, Iksan 570-752, Korea

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.The purpose of this study was to assess and quantify the beneficial effects of gas exchange according to the various frequencies of the sinusoidal wave that are excited by a PZT actuator, on patients suffering from acute respiratory distress syndrome (ARDS). In this study, an experimental method for the flow hydrodynamics was developed through a bundle of sinusoidally vibrated hollow fibers to observe how well vibrations might enhance the performance of the VIVLAD. We measured the effect of the various excitation frequencies of the PZT actuator on the gas transfer rates and hemolysis from the maximum gas transfer rate. As a result, the maximum oxygen transfer rate was reached at the maximum amplitude and through the transfer of vibrations to the hollow fiber membranes. The device was maximum excited by a frequency band of 7 Hz at various water flow rates, as this frequency was the 2nd mode resonance frequency of the flexible beam. 675 hollow fiber membranes were also bundled, within the blood flow, into the device.

Keywords:Artificial Lung;Gas Transfer;Hollow Fiber Membranes;Vibration;Hemolysis

[References]

AAMI Standard: Cardiovascular/Neurology Standards for Blood/Gas Exchanger Devices (Oxygenators); August 14 (1998)
Beek WL, Muttzell KMK, vanHeuven JW, Transport Phenomena(2th ed.), John Wiley & Sons (ASIA) PTE LTD, Singapore, 262 (1999)
Bird RB, Stewart WE, Lightfoot EN, Transport Phenomena(2th ed.), New York, John Wiley & Sons Inc., 675 (2002)
Campell TG, ASAIO J., 40, 109 (1994)
Conrad SA, Artif. Organs, 18, 846 (1994)
Fazzalari FL, Bartlett RH, Bonnel MR, Montoya JP, Artif. Organs, 18, 801 (1994)
Fedespiel WJ, Hout MS, Hewitt TJ, Lund LW, Heinrichm SA, Litwak P, Walters FR, Reeder GD, Borovetz HS, Hattler BG, ASAIO J., 43, M725 (1997)
Gattinoni L, Pesenti A, Rossi GP, Lancet, 2, 292 (1980)
Hewitt TJ, Hattler BG, Federspiel WJ, Ann. Biomed. Eng., 26, 166 (1998)
Ichiba S, Bartlett RH, Artif. Organs, 20, 120 (1996)
ISO/DIS 7199 International Standard: Cardiovascular Implantants and Artificial Organs-Blood-Gas Exchangers (1996)
Kim GB, Kwon TK, Jheong GR, Lee SC, J. Biom. Eng. Res., 24(2), 121 (2003)
Lee SC, Kim KB, J. Biomed. Eng. Res., 23(1), 27 (2002)
Morin PJ, Gosselin C, Picard R, Vincent M, Giundoin R, Nicholl CIH, J. Thorac. Cardiovasc. Surg., 74, 130 (1977)
Mortensen JD, Artif. Organs, 16, 75 (1992)
Mulder M, Basic Principles of Membrane Technology, AA Dordrecht, Kluwer Academic Publishers, Netherlands, 418 (1996)
Naito K, Mizuguchi K, Nose Y, Artif. Organs, 18, 7 (1994)
Nguyen TT, Zwischenberger JB, Tao W, Traber DI, Herndon DN, Duncan CC, Bush P, Bidani A, ASAIO J., 39, M719 (1993)
Nose Y, Recommended Practice for Assessment of Hemolysis in Continous Flow Blood Pump, West Conshohoken, PA: American Society of Testing and Materials, F04:40-41 (1998)
Pesenti A, Gattinoni L, Kobolow T, Damia G, ASAIo Trans., 34, 43 (1988)
Snider MT, Campbell DB, Kofke WA, High KM, Russell GB, Keamy MF, Williams DR, ASAIO Trans., 34, 1014 (1988)
Snider MT, Anesthesiology, 77, 855 (1972)
Streeter VL, Wylie EB, Bedford K, Fluid Mechanics (9th ed.), New York, McGrew-Hill Inc. (1998)
Tanishita K, Richardson PD, Galletti PM, Trans. ASME, 21, 216 (1975)
Vaslef SN, Mockros LF, Anderson RW, Leonard RJ, ASAIO J., 40, 990 (1994)
Weinberger SE, Principles of Pulmonary Medicine, Philadelphia: Saunders (1992)
Weissman HM, Mockros LF, J. Eng. Mech. Div. ASCM., 94, 857 (1968)
Woodhead MA, Respir. Med., 86, 459 (1992)

[Referenced By]

[1] AAMI Standard: Cardiovascular/Neurology Standards for Blood/Gas Exchanger Devices (Oxygenators); August 14 (1998)

[2] Beek WL, Muttzell KMK, vanHeuven JW, Transport Phenomena(2th ed.), John Wiley & Sons (ASIA) PTE LTD, Singapore, 262 (1999)

[3] Bird RB, Stewart WE, Lightfoot EN, Transport Phenomena(2th ed.), New York, John Wiley & Sons Inc., 675 (2002)

[4] Campell TG, ASAIO J., 40, 109 (1994)

[5] Conrad SA, Artif. Organs, 18, 846 (1994)

[6] Fazzalari FL, Bartlett RH, Bonnel MR, Montoya JP, Artif. Organs, 18, 801 (1994)

[7] Fedespiel WJ, Hout MS, Hewitt TJ, Lund LW, Heinrichm SA, Litwak P, Walters FR, Reeder GD, Borovetz HS, Hattler BG, ASAIO J., 43, M725 (1997)

[8] Gattinoni L, Pesenti A, Rossi GP, Lancet, 2, 292 (1980)

[9] Hewitt TJ, Hattler BG, Federspiel WJ, Ann. Biomed. Eng., 26, 166 (1998)

[10] Ichiba S, Bartlett RH, Artif. Organs, 20, 120 (1996)

[11] ISO/DIS 7199 International Standard: Cardiovascular Implantants and Artificial Organs-Blood-Gas Exchangers (1996)

[12] Kim GB, Kwon TK, Jheong GR, Lee SC, J. Biom. Eng. Res., 24(2), 121 (2003)

[13] Lee SC, Kim KB, J. Biomed. Eng. Res., 23(1), 27 (2002)

[14] Morin PJ, Gosselin C, Picard R, Vincent M, Giundoin R, Nicholl CIH, J. Thorac. Cardiovasc. Surg., 74, 130 (1977)

[15] Mortensen JD, Artif. Organs, 16, 75 (1992)

[16] Mulder M, Basic Principles of Membrane Technology, AA Dordrecht, Kluwer Academic Publishers, Netherlands, 418 (1996)

[17] Naito K, Mizuguchi K, Nose Y, Artif. Organs, 18, 7 (1994)

[18] Nguyen TT, Zwischenberger JB, Tao W, Traber DI, Herndon DN, Duncan CC, Bush P, Bidani A, ASAIO J., 39, M719 (1993)

[19] Nose Y, Recommended Practice for Assessment of Hemolysis in Continous Flow Blood Pump, West Conshohoken, PA: American Society of Testing and Materials, F04:40-41 (1998)

[20] Pesenti A, Gattinoni L, Kobolow T, Damia G, ASAIo Trans., 34, 43 (1988)

[21] Snider MT, Campbell DB, Kofke WA, High KM, Russell GB, Keamy MF, Williams DR, ASAIO Trans., 34, 1014 (1988)

[22] Snider MT, Anesthesiology, 77, 855 (1972)

[23] Streeter VL, Wylie EB, Bedford K, Fluid Mechanics (9th ed.), New York, McGrew-Hill Inc. (1998)

[24] Tanishita K, Richardson PD, Galletti PM, Trans. ASME, 21, 216 (1975)

[25] Vaslef SN, Mockros LF, Anderson RW, Leonard RJ, ASAIO J., 40, 990 (1994)

[26] Weinberger SE, Principles of Pulmonary Medicine, Philadelphia: Saunders (1992)

[27] Weissman HM, Mockros LF, J. Eng. Mech. Div. ASCM., 94, 857 (1968)

[28] Woodhead MA, Respir. Med., 86, 459 (1992)