Ionic liquids have been proposed as replacements for volatile organic solvents (VOSs) by a range of authors, due to their very low vapor pressure, ability to dissolve a range of organic, inorganic, and organometallic compounds, immiscibility with water, and ability to form biphasic systems depending on the choice of cation/ anion combination making up the ionic liquid. In this study the room temperature ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] was synthesized and a range of physical properties including the interfacial tension, viscosity, and density determined. The distribution of tyramine and 2-methoxyphenethylamine (MPEA) as a function of pH was determined for the [bmim][PF6] system. This was compared to distribution data obtained for these solutes in conventional organic solvent/water systems: xylene/tributylphosphate (TBP)/water and xylene/Benzyl alcohol (BA)/water.