The design and synthesis of new biomaterials, particularly those derived from biomolecule-based monomers, remains an area of considerable research effort. Herein the synthesis and characterization of poly(carbonate-acetal)s based on stabilized dimer forms of the glucolytic metabolite, dihydroxyacetone, are reported. The polymers possess glass transition (> 40 degrees C) and thermal decomposition (> 300 degrees C) temperatures exceeding those typically associated with aliphatic polycarbonates. The surface free energies of the polymers are significantly influenced by slight substitutions on the DHA dimer, and the polymer thin films support cell growth in culture.