A corrosion resistant microreactor made of PTFE and Tantalum has been developed for the simulation of different nitration reactions. The new microreactor can be easily adapted to the conditions in an industrial plant due to the modular type of construction, and in most cases the results can be directly scaled up and pilot scale plants are not required. The new microreactor can be used for isothermal as well as for adiabatic nitrations, and thermally unstable and sensitive compounds can be produced as the whole reactor can be operated at very low temperatures.