The use of model predictive control (MPC) in middle-vessel continuous distillation column (MVCC) is discussed. It is shown that using a 5 x 5 MPC implementation (where all levels are included in MPC as integral process variables) allows using a smaller middle-vessel, particularly when disturbances can be measured: a good performance is ensured without having the middle vessel drained or overfilled. Also, it is shown that MPC practically circumvents the issue of tuning the middle-vessel level controller. Furthermore, the MVCC design makes conventional decentralised control perform comparably to MPC. (C) 2005 Elsevier Ltd. All rights reserved.